I'm trying to prove that
$$A=\begin{bmatrix} -2 & 2\\ 2 & -5\\ \end{bmatrix}$$
is negative definite. I can do it using the principal minors, but I am trying to understand how to do it using only the definition of a negative definite matrix, i.e., using the quadratic form associated with it.
Definition. A real symmetric matrix $A$ is called positive definite if $x^\intercal A x > 0$ for every real nonzero vector $x$ of compatible size.
Definition. A matrix $A$ is called negative definite if the matrix $-A$ is positive definite.
In your case, $$ x^\intercal (-A) x = \cdots = 2(x_1 - x_2)^2 + 3x_2^2, $$ as desired. You should work through the missing steps to verify the above.
Remark. Your matrix $-A$ happens to be a weakly chained diagonally dominant L-matrix. By a well-known result, this means that it is an M-matrix. A symmetric M-matrix is also called a Stieltjes matrix. Stieltjes matrices are positive definite.