How to solve this equation system?
$$\frac{-1}{x_1^{2} x_2 x_3} +y(x_2+2x_3) = 0, $$
$$x_3- \frac{1}{x_1 x_2^{2} x_3} + y x_1 = 0, $$
$$x_2 - \frac{1}{x_1 x_2 x_3^{2}} + 2yx_1 = 0, $$
$$x_1 x_2 + x_1 x_3 = 4 $$
where $x_1,x_2,x_3,y \neq 0$.
I have tried, but I can't get something. It seems unclear how to express one variable in terms of the others.
If you are satisfied with a computational solution then one may consider the variety $V \subset \mathbb{A}^4_{x_1, x_2, x_3, y}$ given by
\begin{align*} x_1^2 x_2^2 x_3 y + 2 x_1^2 x_2 x_3^2 y - 1 = 0 \\ x_1^2 x_2^2 x_3 y + x_1 x_2^2 x_3^2 - 1 =0\\ 2 x_1^2 x_2 x_3^2 y + x_1 x_2^2 x_3^2 - 1 =0\\ x_1 x_2 + x_1 x_3 - 4 =0 \end{align*} these are the numerators of your rational functions - i.e., this condition holds when $x_1,x_2,x_3,y \neq 0$ if and only if your condition holds.
The variety $V$ has dimension $0$ and (over $\mathbb{Q}$) has exactly one irreducible component. However it has no rational points i.e., your original equation has no solution in $\mathbb{Q}$.
However, let $\alpha \in \mathbb{C}$ be a root of $f(x) = x^4 - 4x^2 - 12x +4$. Then over $K = \mathbb{Q}(\alpha)$ (and indeed over $\mathbb{C}$) there are exactly $4$ solutions to the original system, namely \begin{align*} (x_1, x_2, x_3, y) = \left( \frac{4\alpha^2 - 8}{9}, \frac{\alpha^3 - 2\alpha - 12}{4}, \frac{\alpha^3 - 2\alpha - 12}{8}, \frac{9\alpha^3 + 3\alpha^2 - 36\alpha - 114}{64} \right) \end{align*} and its Galois conjugates (i.e., replace $\alpha$ by the other $3$ roots of $f(x)$).
All of these claims were checked with Magma as follows: