$$ \sum_{r=0}^n \frac{(-1)^r}{n+r+1} {n \choose r} = \frac{ \sqrt{\pi}~ 2^{-2n-1} n ! }{ \left(n + \frac{1}{2} \right)! } $$
How to explain what is the left series become to right form? I calculated by wolfram and received it but I couldn't that how to transform from a combination formula in the left series to the useful tool(ex: factorial or double). so I don't know about concrete solution. (sorry, I'm not good at English because I was born in korea. If you don't like this terrible sentence, Please forgive me...)
To evaluate the LHS introduce
$$f(z) = (-1)^n n! \frac{1}{z+n+1} \prod_{q=0}^n \frac{1}{z-q}.$$
This has the property that
$$\mathrm{Res}_{z=r} f(z) = (-1)^n n! \frac{1}{r+n+1} \prod_{q=0}^{r-1} \frac{1}{r-q} \prod_{q=r+1}^n \frac{1}{r-q} \\ = (-1)^n n! \frac{1}{r+n+1} \frac{1}{r!} \frac{(-1)^{n-r}}{(n-r)!} = \frac{1}{r+n+1} (-1)^r {n\choose r}.$$
As we seek to compute
$$\sum_{r=0}^n \frac{1}{r+n+1} (-1)^r {n\choose r}$$
and residues sum to zero with the residue at infinity being zero by inspection we get for our sum
$$-\mathrm{Res}_{z=-n-1} f(z) = - (-1)^n n! \prod_{q=0}^n \frac{1}{-n-1-q} = n! \prod_{q=0}^n \frac{1}{n+1+q} \\ = \frac{n!\times n!}{(2n+1)!}.$$
On the other hand working with the RHS we have with the Legendre duplication formula
$$\frac{\sqrt{\pi} 2^{-2n-1} n!}{(n+1/2)!} = \frac{\sqrt{\pi} 2^{-2n-1} n!}{\Gamma(n+3/2)} \\ = \frac{\sqrt{\pi} 2^{-2n-1} \times n! \times n!} {\Gamma(n+1) \Gamma(n+3/2)} \\ = \frac{\sqrt{\pi} 2^{-2n-1} \times n! \times n!} {2^{1-2(n+1)} \sqrt{\pi} \Gamma(2n+2)} = \frac{n!\times n!}{(2n+1)!}.$$
We see that the LHS and the RHS are identical as claimed.