There is no isometry between a $(1,3)$-signatured and a $(3,1)$-signatured Minkowski space, but in spite of this, they "look like" the same, for example, they have the same light cone. Is there any treatment (category) which defines a special kind of isomorphism so that $(1,3)$ and $(3,1)$-signatured Mikowski spaces are isomorhic (or the same)?
Edit: perhaps we should regard the Zeeman-topologies?
Suppose $(V_1, q_1), (V_2, q_2)$ are $4$-dimensional vector spaces equipped with quadratic forms $q_1, q_2$ of signatures $(3,1)$ and $(1,3)$ respectively. Let $G_1, G_2$ denote the automorphism groups of the forms $q_1, q_2$, i.e. of linear transformations preserving the respective forms. Then the groups $G_1, G_2$ are isomorphic ($O(3,1)\cong O(1,3)$). More precisely, there exists an invertible linear map $L: V_1\to V_2$ such that:
$L_*(q_1)=-q_2$, i.e. for every vector $v\in V_1$ we have $$ q_2(L(v))= -q_1(v). $$
$L G_1 L^{-1}= G_2$.
Hence, the linear map $L$ preserves everything we care about when working with Lorentzian geometry.
One more thing: The same works for vector spaces equipped with quadratic forms of signatures $(p,q)$ and $(q,p)$, for instance, you can take the form $q_1$ to be positive-definite and $q_2$ negative-definite.
As for complexifying: This would be cheating since after that even forms of signatures $(3,1)$ and $(2,2)$ become isomorphic.