I'm trying to use the substitution $x=\frac{1}{4}\sec{\theta}$.
This turns $\sqrt{16x^2-1}$ into $\tan{x}$.
Implicit differentiation gives us $dx = \frac{1}{4} \tan{\theta}\sec{\theta} d\theta$.
Then, $\int\sqrt{16x^2-1} dx = \frac{1}{4}∫\tan^2{\theta}\sec{\theta}d\theta$.
I'm attempting to use Integration by Parts to integrate, but its just taking me around in loops...

This is a fun one. Let $$I = \int \tan^2\theta \sec\theta d\theta$$ Using integration by parts with $u=\tan\theta, dv=\sec\theta\tan\theta$, $$I = \sec\theta\tan\theta - \int\sec^3\theta d\theta = \sec\theta\tan\theta - \int(1+\tan^2\theta)\sec\theta d\theta = $$$$\sec\theta\tan\theta-I - \int \sec\theta d\theta = \sec\theta\tan\theta-\ln(\sec\theta+\tan\theta)-I$$ Thus, solving for $I$, $$I = \frac{1}{2}(\sec\theta\tan\theta - \ln(\sec\theta+\tan\theta))+C$$ FYI, taking the integral of $\sin(x)e^x$ is similar to this.