Integration: How to generally pick "$u$" in substitution and some specific examples I had to do

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I have been doing integration by substitution. And I wonder whether there is a general method or approach, as to what I can pick as $u$. I have had these specific tasks, were the teacher gave a hint as to what $u$ should be and the rest we had to solve ourselves:

  1. $\int\ln(1+\sqrt{x})\,dx\quad$ Hint: $u=1+\sqrt{x}$.

  2. $\int \frac{e^{\sqrt{x}}}{\sqrt{x(1+e^{\sqrt{x}})}}\,dx\quad$, Hint: $u=1+e^{\sqrt{x}}$

  3. $\int \frac{x}{\sqrt{a^2-x^2}}\,dx\quad$ Hint: $u=a^2-x^2$

But how can he see what should be picked as $u$? My experience is that what is picked for $u$ is that what is the least complex. Which means that picking the entire denominator for $u=\sqrt{x(1+e^{\sqrt{x}})}$ in (2) and the same for (3) $u=√a^2-x^2$, would lead nowhere or would be too complex. Or do you disagree would it be just as good picking the entire denominator in (2) and (3)?

Thank you.

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Too long for a comment.

u substitution is essentially a reverse chain rule. The change rule allows you to take the derivative of a composite function with respect to its argument, then multiply by the derivative of the argument with respect to $x$. u sub does something similar. So you want to focus on i) the argument of a composite function ii) with an eye out for a manipulation of the argument that already has a factor of its derivative in the integrand.

For problem 1, $u=1+\sqrt{x}$. There's no opportunity for part of the argument's derivative to appear in the integrand.

For problem 2, there are multiple possibilities based on that principle. Note $1/\sqrt{x}$ is a factor of the integrand and $\sqrt{x}$ occurs as an argument multiple times. $(\sqrt{x})'=1/2\sqrt{x}$ So $u=\sqrt{x}$ is a good choice, though not the best.

$\frac{e^{\sqrt{x}}dx}{\sqrt{x(1+e^{\sqrt{x}})}}=\frac{e^udu}{2\sqrt{1+e^u}}$

Then you can apply the same principle again. The only composite function now is $\sqrt{1+e^u}$ and conveniently its derivative is a factor of the integrand already in place. This suggests we let $v=1+e^u\implies dv=e^udu$

$\frac{e^udu}{2\sqrt{1+e^u}}=\frac{dv}{2\sqrt{v}}$

Using $v=1+e^{\sqrt{x}}$ would have cut to the chase, but either way is pretty quick.

Problem 3 is pretty clear. There's only one composite function and a scalar multiple of its derivative is in the integrand.

In general, substitution takes $\int f(g(x))g'(x) dx$ to $\int f(u)du$ via $u=g(x)$.

So good rule of thumb focus on arguments of the composite function and multiples of its derivative.