Why does the integral of the function $\frac{1}{x}$ from 1 to $e$ have to be equal to 1 ?
Why does it mathematically make sense?
How come a number related to instantaneous, continuous growth has to appear under the curve of $\frac{1}{x}$ in particular?
Why is the area under this curve related to exponentiation?
Thank you.
EDIT : I do not mind formal mathematics as long as the answer conveys the intuition that would help answering these questions.

I think, it's easier to introduce the constant $e$ first. This constant provides solutions to the ordinary differential equation:
$${dy \over dt} = y.$$
In other words, it helps answer the question about invariants (https://en.wikipedia.org/wiki/Invariant_(mathematics)): Which functions are their own derivatives?
Using the power series approach, $y(t) = \sum_{k \geq 0} a_{k} t^{k}$, we arrive at $a_{k} = 1 / (k!)$.
Now, since it turns out that the function $f(x) = e^{x}$ is a bijection from the real line to the real strictly positive half-line $y > 0$, one can ask: What is the inverse of $f(x)$? That's how we arrive at the natural logarithm $\ln(y)$.
Finally, what is the rate of change of $\ln(y)$ with respect to $y$? Well, by the above,
$$ 1 = {dy \over dy} = {d \over dy} (e^{\ln y}) = e^{\ln y} {d \over dy} \ln(y). $$ (The last equality is the Chain Rule.)
That gives the rate relations you were asking about.
The definite integral $\int_{1}^{e} {dx \over x}$ can now be computed using the above and the Fundamental Theorem of Calculus.