For two vectors $\mathbf{u, v}$ with $n$ real positive entries each and an $n$-by-$n$ real symmetric matrix $\mathbf{M}$, I'm thinking that
$$\mathbf{u} \cdot \mathbf{M} \cdot \mathbf{v} > a\mathbf{u \cdot v}$$
Where $a$ is a real scalar between 0 and 1.
First, is this inequality true? Second, why?
EDIT:
The kind of matrix I have in mind for $\mathbf{M}$ is
$$\mathbf{M=X^{-1}D(q)X}$$
Where $\mathbf{X}$ is an $n$-by-$n$ symmetric matrix with real, non-zero entries, $\mathbf{D(q)}$ is a matrix whose diagonal elements are those of the vector $\mathbf{q}$ (which are generally between 0 and 1), and with zeroes elsewhere.
From what I can tell, there's no general easy statement that we can make about the inequality based the information you've provided; you can get both directions depending on $M$ and $a, u, v$.
Instead, I'd suggest that you look at the eigenvalues of $M$. Specifically, let $z = \text{tr}(M)$. Then if we take $a \sim unif(0,1)$ and similarly for the entries of vectors $q, u, v$, then with probability $z/n$ we have the original direction.
I played around with the following MATLAB script below:
Try replacing $q$ with
q = repmat(p, n, 1);to see the probability change to $p$.