Assume that $M$ is a compact simply connected Riemannian manifold and $f$ is a conformal diffeomeorphism of $M$. Is it true to say that $f$ is homotopic (or isotopic) to an isometry of $M$?
What would be the answer if we drop the simply connected assumption?
I don't think that this can be true in the form you state it. The point is that you can replace the given metric on $M$ by any conformal rescaling without changing the the conformal diffeomorphisms. However, a generic conformal rescaling of a given metric on $M$ should not admit any isometries. So you would end up with the statement that any conformal diffeomorphism is homotopic to the identity.