Is there any difference between $\mathbb{R} \times \mathbb{R} \times \mathbb{R}$, $\mathbb{R} \times \mathbb{R}^2$ and $\mathbb{R}^2 \times \mathbb{R}$?
Two of them have two coordinates, a scalar and a vector. The first one is clearly the 3-dimensional space $\mathbb{R}^3$. But what about the other two?
Is there any topological difference?
As mentioned in the comments we usually view these as formally different objects: An element of $\Bbb R^3$ is a triple of elements in $\Bbb R$, whereas an element of $\Bbb R \times \Bbb R^2$ is a pair whose first component is a point of $\Bbb R$ and whose second is an element of $\Bbb R^2$. There are however, canonical bijections between these sets, e.g., $$\Bbb R^3 \leftrightarrow \Bbb R \times \Bbb R^2, \qquad (x, y, z) \leftrightarrow (x, (y, z)) ,$$ and these bijections will respect most familiar structures you might put on these sets. For example, if we give $\Bbb R^k$, $k = 1, 2, 3$, the usual vector addition and scalar multiplication rules, these bijections are vector space isomorphisms.
A choice of topology $\tau$ on $\Bbb R$ determines product topologies $\tau^k$ on $\Bbb R^k$, $k > 1$, and for any choice of $\tau$, e.g., the above bijection is a homeomorphism $(\Bbb R^3, \tau^3) \cong (\Bbb R \times \Bbb R^2, \tau \times \tau^2)$, where $\tau \times \tau^2$ is the product topology of $\tau$ and $\tau^2$. For general choices of topologies on $\Bbb R, \Bbb R^2, \Bbb R^3$, however, they will not be homeomorphisms.