I'm not sure how I can show the following:
If $F \colon \mathcal{A} \to \mathcal{B}$ is a left exact functor from an abelian category $\mathcal{A}$ to an abelian category $\mathcal{B}$, whose derived functor $\mathbf{R}F$ in the sense of derived categories exists, then the following holds:
If $Z^\bullet$ is a complex consisting of $F$-acyclic objects in $\mathcal{A}$, then $\mathbf{R}F(Z^\bullet)$ is equal to $\mathbf{K}F(Z^\bullet)$; with the last symbol I just mean: apply $F$ to the complex $Z^\bullet$ and understand the result as belonging to $\mathbf{D}^{+}(\mathcal{B})$.
I don't want to assume the existence of $F$-adapted classes or enough injectives, just the existence of $\mathbf{R}F$.
Thanks a lot!
With the proper definitions you have the following facts. I'll be using Keller's terminology in Derived Categories and their uses:
This implies the following:
Piecing 3. and 4. together we get that $\mathbf{R}F$ is defined at every $Z \in K^{+}(Ac)$ and $FI(Z) = \mathbf{R}(FI)(Z) = \mathbf{R}F \mathbf{R}I(Z) = \mathbf{R}F(IZ)$ with a slight abuse of notation that you'll hopefully allow me to make. Neglecting the inclusion functor $I$ we get $F(Z) = \mathbf{R}F(Z)$ as you wanted.
So that's the argument. Now Keller's text does not provide too many details but it gives sufficiently many for following through the entire argument. Sections 6.7 and 6.6 in Derived Categories and Universal Problems may be helpful when verifying Proposition 13.1. and Lemma 13.6, as well as Deligne's text Cohomologie à supports propres, SGA 4 Vol. 3, Exposé XVII, Springer LNM 305 (1973).
Some Further References: