$\newcommand{\S}{\mathbb{S}^1}$Let $M=\{(x,y,z) \in (\S)^3 \, |\,\, x,y,z \,\,\text{are distinct}\}$.
Is $M$ homeomorphic to a finite union of products of one-dimensional manifolds?
I think $M$ is not connected, so it cannot be homeomorphic to a product.
$M$ is not connected, since if $x-y-z$ are ordered clockwise, you cannot move to $x-z-y$ being clockwise.
So I think that there are two connected components.
The case where considering pairs follows easily from the group structure of $\mathbb{S}^1$.
$\newcommand\S{{\mathbb S}^1}\newcommand\quad{ \ \ \ \ }$This answer is very similar to Greg's answer but I think it becomes slightly clearer if we insted use the multiplicative structure of the circle. We therefore view $\S$ as the unit circle in the complex plane, which is a group under multiplication.
Consider the homeomorphism $$ \varphi : (x,y,z)\in (\S)^3 \mapsto (z^{-1}x,z^{-1}y,z)\in (\S)^3 $$ and observe that $$ x=z \Leftrightarrow \varphi (x,y,z)\in \{1\}\times \S\times \S, $$ $$ y=z \Leftrightarrow \varphi (x,y,z)\in \S\times \{1\}\times \S, $$ $$ x=y \Leftrightarrow \varphi (x,y,z)\in \quad \ \Delta \quad\ \times \S, $$ where $\Delta $ is the diagonal of $\S\times \S$, that is, $\Delta =\{(u, v)\in \S\times \S: u=v \}$. It follows that $$ \varphi (M) = X\times \S, $$ where $X$ is the subset of $\S\times \S$ that we get after throwing away $$ \big (\{1\}\times \S\big ) \cup \big (\S\times \{1\}\big ) \cup \Delta . $$ Viewing $\S\times \S$ as a closed square, where we identify the bottom and top sides, as well as the left and right sides,
removing $\{1\}\times \S$ corresponds to removing the left (and hence also the right) side of the square,
removing $\S\times \{1\}$ corresponds to removing the bottom (and hence also the top) side, while
removing the diagonal is, well, removing the diagonal.
We are then left with an open square minus the diagonal, hence two disjoint open triangles!