This is kind of two questions in one.
Firstly, does the following expression have a closed form?
$$\sum_{i=0}^k \binom{n}{i}x^i$$ $$\text{(first $k$ terms in binomial series)}$$
where $k$ is some integer $0 < k < n$.
Secondly, this question got me thinking: is there a way to know if an expression does not have a closed form? If the above expression has no closed form, how would I know?
The direct answer: No, there exists no closed-form expression for the partial sum of binomial coefficients.
The extended answer: There does exist an expression that uses the Gaussian hypergeometric function $_2F_1$, but it isn't considered closed-form (shorter version of Claude Leibovici's answer):
$$\sum_{i=0}^k \binom{n}{i}x^i = (1+x)^n - x^{k+1} \binom{n}{k+1} \, _2F_1(1,k-n+1;k+2;-x)$$
Thanks to mr_e_man who supplied me with these two links:
Calculating partial sum of binomial coefficients fast
Is there a simpler (preferably closed-form) way to compute this sum of binomial coefficients?