If $(X,\|\cdot\|)$ is a semi-normed vector space.
It is always possible to define a topology on $X$? If it is true What is the definition of a closed subspace of $X$ with respect to $\|\cdot\|$?
I guess that a subspace $M$ of $X$ is closed with respect to the semi-norm $\|\cdot\|$ if and only if every $(x_n)_n\subset M$ such that $\|x_n-x\|\to 0$ then $x\in M$.
A semi-norm $p$ directly induces a topology: the neighborhoods of a point $x$ are sets $U(x, r) = \{y:p(x-y)<r\}$. The topology gives you the concepts of open and closed sets. And yes, a closed subspace $M$ can be characterized by sequences: $M$ is closed iff $p(x_n, x)\to 0$ with $x_n\in M$ implies $x\in M$.
However, the above topology is not Hausdorff unless $p$ is a norm. Indeed, every neighborhood of $0$ contains the set $\{x:p(x)=0\}$. As Wikipedia notes,
The point being, there is not much to do with the space in its current form. If you are willing to take the quotient $X/\{x:p(x)=0\}$, that's one way to rectify the situation; the quotient is Hausdorff.
But I don't think there is any canonical way to get a Hausdorff topology on a seminormed space $X$ itself. See a related question Turning a semi-norm into a norm.