Joint distribution of two conditional distributions

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I am trying to understand how a joint distribution is formed when two regular conditional distributions are involved that are conditional with respect to different random variables.

Let $(\Omega, \mathcal{A}, \mathbb{P})$ be a probability space, and let there be the three random variables $X:(\Omega, \mathcal{A})\rightarrow (\mathcal{X}, \mathcal{F})$, $Y:(\Omega, \mathcal{A})\rightarrow (\mathcal{Y}, \mathcal{G})$, $Z:(\Omega, \mathcal{A})\rightarrow (\mathcal{Z}, \mathcal{H})$. Let us consider the Markov kernels $\mathbb{P}_{Y|X}$ and $\mathbb{P}_{X|Z}$.

1.) My question now is, if $$\int_{\mathcal{X}}\mathbb{P}_{Y|X=x}(E) \mathbb{P}_{X|Z=z_0}(dx)=\mathbb{P}_{Y, X|Z=z_0}(E)$$ holds (for some fixed $z_0$)?

On the one hand I would say no because intuitively I would assume that we would need a kernel $\mathbb{P}_{Y|X, Z}$ for that. On the other hand, for some fixed $z_0$, $\mathbb{P}_{X|Z=z_0}$ is simply a measure on $\mathcal{X}$ and not a conditional distribution (i.e., a kernel) anymore, so by that logic the above equation would make sense. Can someone shed light on this?

2.) What is the difference between $\mathbb{P}_{Y, X|Z=z_0}(E)$ and $\mathbb{P}_{Y, X}(E)$ anyway, since both are measures on $\mathcal{X}\times\mathcal{Y}$, so how does the conditioning on a fixed $z_0$ even makes a difference? Can somebody tell me how exactly these two quantities differ?

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The correct is: $$\int_D d\mathbb{P}_{X/Z}\int_E d\mathbb{P}_{Y/X,Z}=\mathbb{P}_{X,Y/Z}(D\times E)$$ Logically, if $D=\mathcal{X}$: $$\mathbb{P}_{X,Y/Z}(\mathcal{X}\times E)=\mathbb{P}_{Y/Z}(E)$$

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If $Y$ and $Z$ are conditionally independent when given $X$, then

$$\begin{align}\mathsf P_{X,Y\mid Z=z}(x,y\mid z)=\mathsf P_{Y\mid X=x}(y)\,\mathsf P_{X\mid Z=z}(x)\\\mathsf P_{Y\mid Z=z_0}\!(E)=\int_\mathcal X \mathsf P_{Y\mid X=x}(E)\,\mathsf P_{X\mid Z=z_0}\!(\mathrm dx)\end{align}$$

If that was not the case, then:

$$\begin{align}\mathsf P_{X,Y\mid Z=z}(x,y\mid z)=\mathsf P_{Y\mid X=x,Z=z}(y)\,\mathsf P_{X\mid Z=z}(x)\\\mathsf P_{Y\mid Z=z_0}\!(E)=\int_\mathcal X \mathsf P_{Y\mid X=x,Z=z_0}\!(E)\,\mathsf P_{X\mid Z=z_0}\!(\mathrm dx)\end{align}$$