Are there mathematical disciplines that are extremely inaccessible, with very high thresholds even for those who have the necessary prerequisites?
Number theory and graph theory, for example, are very complicated in themselves, but everyone can still form an idea of what it's all about. Also, category theory is relatively easy to understand, although the definitions and methods are very abstract.
General topology is more abstract from scratch and many get lost (just unnecessary). Those who practice the methods of analysis understand the importance of open sets, but it is not easy to develop a proper intuition.
Many people have problems with homological algebra, in my opinion because they misunderstand the diagrams: large charts do not mean more difficult problems, but more information; the diagram is just a very efficient way to display information that facilitates problem solving with a few standard methods.
However, I ask for very inaccessible disciplines which are fundamentally difficult to understand even for mathematicians with prior knowledge.
Here are two examples by changing our underlying logic (perhaps someone else can comment on "Inter-universal Teichmüller theory" since I know nothing about it except that it is hard to get into):