Negative exponents on a quantity in scientific notation considering significant figures

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Are there rules that apply to negative exponents with regard to scientific notation? The specific problem is:

$$\left(6.3\times10^{2}\right)^{-6}$$

I believe the following is correct:

$$\frac{1}{\left(6.3\times10^2\right)^6}$$

However is there a rule that we can apply to the exponent (similar to the rule of multiplying means adding exponents and division means subtracting exponents)? Forgive me as this is a very simple problem, I am back teaching Chem after many years and for some reason this is escaping me.

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If I understand the question, then what you wrote is correct. You can verify properties of exponentiation on corresponding Wikipedia page, for example. In particular, \begin{align} \big(\,b^m\,\big)^n &= b^{m\cdot n}& \text{ and }& & b^{-n} &= \dfrac{1}{b^n} \end{align}

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I think the rule you are looking for is that

$$ \left(x^a\right)^b = x^{ab}.$$

Applying it to your case:

$$\left(6.3\times10^{2}\right)^{-6}=\left(6.3^{-6}\times10^{-12}\right)\approx 1.599398 \times 10^{-17}.$$