Let $G$ be and $m \times n$ matrix of full-rank $n \le m$ in particular, and let $\Delta_n := \{x \in \mathbb R^n \mid x_1,\ldots,x_n \ge 0,\;\sum_{i=1}^n x_i = 1\}$ be the $(n-1)$-dimensional unit simplex. Define $s(G)$ by $$ s(G) := \inf_{x \in \Delta_n} \|Gx\|. $$
Question. Is there a nontrivial lower-bound for $s(G)$ in terms of simpler quantities (say, it terms of a function of the singular-values of $G$, etc.) ?
For a trivial bound, note that $$ s(G) \ge \inf_{x \in \Delta_n} s_{\min}(G)\|\cdot\|x\| = s_{\min}(G) \cdot \inf_{x \in \Delta_n} \|x\| = s_{\min}G)/\sqrt{n}, $$
where $s_{\min}(G) := \inf_{\|x\|=1} \|Gx\|$ is the least singular-value of $G$.
You can get a lower bound by omitting the nonnegativity constraint. The problem becomes: $$\min_{x \in \Delta_n} \{ x^T G^TG x : e^Tx = 1 \}.$$ Note that this is a convex optimization problem that satisfies the Slater condition, so the KKT conditions are necessary and sufficient. The Lagrangian is $L(x,y) = x^T G^TG x + y(e^Tx - 1)$, and setting its derivatives to $0$ results in the following KKT system: $$\begin{pmatrix}2G^TG & e \\ e^T & 0\end{pmatrix} \begin{pmatrix}x \\ y \end{pmatrix} = \begin{pmatrix} 0 \\ 1 \end{pmatrix}.$$ Solving for $x$ and computing $||Gx||$ gives a lower bound.
Instead of solving via the Lagrangian, you can also eliminate the last element of $x$ by writing it as $x_n = 1-e^T\tilde{x}$, which gives an unconstrained quadratic objective function.