What are the number of natural solutions to $$x_1 + x_2 + x_3 + 2x_4 + x_5 = 72$$ where $x_1 \ge 2, x_2, x_3 \ge 1, x_4, x_5 \ge 0$?
I understand how to do it if it wasn't "$2x_4$", hence if the coefficient of $x_4$ was $1$, , then the answer will be $C(72,4) \ldots \ $, but given $2x_4$, I don't know how to solve the question.
Move $2x_4$ to the other side and solve a separate $4$-variable problem for each possible value of $x_4$. In other words, you’re counting non-negative solutions to
$$x_1+x_2+x_3+x_5=68-2k$$
for $k=0,\ldots,34$, and you get
$$\sum_{k=0}^{34}\binom{71-2k}3=\sum_{k=1}^{35}\binom{2k+1}3\;.$$
This actually isn’t quite as nasty as it may look. If we calculate the first few values of $$a_n=\sum_{k=1}^n\binom{2k+1}3\;,$$ we get $a_1=1$, $a_2=10$, $a_3=35$, and $a_4=84$, with first differences $9$, $25$, and $49$. That suggests that we’re looking at sums of odd squares, i.e., that
$$\begin{align*} \sum_{k=1}^{n+1}\binom{2k}3&=\sum_{k=1}^n(2k-1)^2\\ &=4\sum_{k=1}^nk^2-4\sum_{k=1}^nk+\sum_{k=1}^n1\\ &=\frac23n(n+1)(2n+1)-2n(n+1)+n\\ &=\frac13n(4n^2-1)\;. \end{align*}$$
This can be straightforwardly proved by induction on $n$.