Let $K$ be a number field and let $p$ denote an odd prime. We let $H(K)$ and $M(K)$ denote the maximal $p$-abelian everywhere unramified extension of $K$ and the maximal $p$-abelian $p$-ramified extension of $K$, respectively. Let $\mathfrak{p}_1, \ldots, \mathfrak{p}_s$ denote the primes in $K$ above $p$, and for each $i=1,\ldots, s$, let $U_i$ denote the local units in $K_{\mathfrak{p}_i}$ which are one modulo $\mathfrak{p}_i$. We also let $$U(K)=\prod\limits_{i=1}^s U_i$$ and we denote by $E(K)$ the units of $K$ which embed diagonally in $U(K)$. Class field theory gives an isomorphism $$Gal(M(K)/H(K)) \cong U(K)/\overline{E(K)}.$$
My questions is: if we let $K_{\infty}$ denote the cyclotomic $Z_p$-extension of $K$, is there a similarly nice description of the Galois group $Gal(M(K)/K_{\infty}\cdot H(K))$?
When $K=\mathbb{Q}(\zeta_p)$, I found some references which prove that $$Gal(M(K)/K_{\infty}\cdot H(K)) \cong U'(K)/\overline{E(K)},$$ where $U'(K)$ is the subgroup of elements in $U(K)$ which have norm $1$ to $\mathbb{Q}_p$. Does this result generalize to arbitrary number fields, or at least those which contain $\zeta_p$?
Your notations are not very good because it is not visible at first sight that you deal only with $\mathbf Z_p$-modules. Anyway, keep $E(K)$ but change the notation $U(K)$, which will now be the product over all $p$-places of the local units, and introduce $U^1(K)$ = the product of the principal local units. Moreover, for simplification, put $Y(K) = Gal(M(K)/K)$ and $X(K)=Gal(H(K)/K)$. Instead of the isomorphism that you recalled, I'd rather write down the so called "CFT exact sequence relative to inertia":
(In) $ 1\to \Delta(K)\to E(K) \otimes \mathbf Z_p \to U(K) \otimes \mathbf Z_p = U^1(K) \to Y(K) \to X(K) \to 1$ ,
where the global-local map $E(K) \otimes \mathbf Z_p \to U(K) \otimes \mathbf Z_p $ is the diagonal embedding (its image is your $\bar E{(K)}$) , the local-global map $U^1(K) \to Y(K)$ is CFT, and the map $Y(K) \to X(K)$ is the natural surjection; the kernel $\Delta(K)$ is the so called Leopoldt kernel, whose vanishing constitutes the famous Leopoldt conjecture. Note that $X(K)$ is finite, but $Y(K)$ is not; actually, if $c$ is the number of complex primes of $K$, one can derive from (In) that $rank_{\mathbf Z_p} Y(K)=1 + c +rank_{\mathbf Z_p} \Delta(K)$. In this setting, it is more natural to consider the "CFT exact sequence relative to decomposition" : let $E'(K)$ be the group of global $p$-units ( = units outside the $p$-primes), $X'(K)=Gal(H'(K)/K)$, where $H'(K)$ is the subfield of $H(K)$ in which all the $p$-places $v$ of $K$ are totally decomposed; for a local field $K_v$, introduce the pro-$p$-completion $\hat K_{v}= \varprojlim K^*_v/(K^*_v)^{p^n}$, and denote by $\hat U(K)$ the product over all $p$-places of the $\hat K_{v}$'s ; then we have the exact sequence :
(Dec) $ 1\to \Delta(K)\to E'(K) \otimes \mathbf Z_p \to \hat U(K) \to Y(K) \to X'(K) \to 1$
NB. There is a subtlety here. The pro-$p$-completions of $E(K), E'(K)$ and $U(K)$ are $E(K) \otimes \mathbf Z_p$, $E'(K) \otimes \mathbf Z_p$ and $U(K) \otimes \mathbf Z_p$ because $E(K), E'(K)$ and $U(K)$ are $\mathbf Z$-modules of finite type, which not the case of $K^*_v$.
Now, given any $\mathbf Z_p$-extension $K_\infty /K$, you can take the proj. lim. relative to norms of (In) and (Dec) along the finite subextensions $K_n$ of $K_\infty /K$ to get analogous exact sequences at infinite level. Because of the functoriality of CFT w.r.t. norm maps, the proj. lim. $Y(K_\infty), X(K_\infty), X'(K_\infty)$ are subject to the same Galois theoretic interpretation over $K_\infty$ as previously $Y(K), X(K), X'(K)$ over $K$. If $K_\infty$ is specifically the cyclotomic $\mathbf Z_p$-extension, it is known that the Leopoldt defects $\Delta(K_n)$ are bounded, and their proj. lim. is null ./.