Is it possible that an oriented Riemannian manifold $(M,g)$ with a large isometry group $\text{Isom}(M,g)$ has an orientation reversing self-diffeomorphism but no orientation reversing self-isometry, i.e. $\text{Isom}(M,g) \subseteq \text{Diff}^+(M)$? "Large" should mean something like $\dim \text{Isom}(M,g) \geq 1$.
Can one detect such manifolds resp. Riemannian metrics in an easy way, if they exist?
This is probably not what you want, but you can take any manifold that admits an orientation-reversing self diffeomorphism and equip it with a generic metric that does not admit any self-isometry to get an example. So in a way, this what should happen "typically".