Points on two skew lines closest to one another

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Given two skew lines defined by 2 points lying on them as $(\vec{x}_1,\vec{x}_2)$ and $(\vec{x}_3,\vec{x}_4)$. What are the vectors for the two points on the corrwsponding lines, distance between which is minimum? That distance is thus but what are the points where it is achieved?

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HINT: You're looking for points $P$ and $Q$ on the respective lines for which the vector $\overrightarrow{PQ}$ will be orthogonal (perpendicular) to both lines. (To understand why, think about the hypotenuse of a right triangle.) So, for starters, you want a vector orthogonal to both $\vec x_2-\vec x_1$ and $\vec x_4-\vec x_3$.