The problem statement is
Let $a_1,a_2,\dots,a_n$ be a strictly decreasing sequence of positive integers, with $a_1\equiv5\ (\text{mod }8)$.
Prove that for all positive integers $n$, if $$a_1+a_2+\dots+a_n\le2^{n-4}\text,$$ then for all positive integers $m$, $$a_2!a_3!\dots a_n!+1\neq a_1^m\text.$$
Consider that if $n\le6$, the statement is never false, since the antecendent never holds (because $2^{n-4}\le2^{6-4}=4$ and $a_1+a_2+\dots+a_n\ge a_1\ge5$).
It remains to prove the statement for $n\ge7$.
I set out to prove it by contradiction, assuming $a_1+a_2+\dots+a_n\le2^{n-4}$ and $a_2!a_3!\dots a_n!+1=a_1^m$ for some positive integer $m$.
What I obtained:
Because $a_1\equiv5\ (\text{mod }8)$, we have $a_1^m\equiv5\ (\text{mod }8)$ if $m$ is odd, and $a_1^m\equiv1\ (\text{mod }8)$ if $m$ is even.
Because $n\ge7$ and the sequence is strictly decreasing, we have $a_2\ge6$ (otherwise, $a_7$ would not be positive). Therefore, $8\mid720\mid a_2!$. It follows that $a_2!a_3!\dots a_n!+1\equiv1\ (\text{mod }8)$.
From (1) and (2), we obtain that $m$ is even.
Consider that $(a_2!a_3!\dots a_n!,a_2!a_3!\dots a_n!+1)=1$, where $(a,b)$ denotes the greatest common divisor of $a$ and $b$. It follows that $$(a_2!a_3!\dots a_n!,a_1^m)=1\\ \implies(a_2!,a_1)=1\text;$$ in other words, $a_1$ is relatively prime to $a_2!$. It follows that the smallest prime factor (and thus any prime factor) of $a_1$ is larger than $a_2$.
But I couldn't get much further.
Just an observation, without using $a_1 \equiv 5 \pmod{8}$ ...
Let's look at the least possible cases: $$a_n=1 \Rightarrow a_n!=1$$ $$a_{n-1}>a_n \Rightarrow a_{n-1}\geq2 \Rightarrow a_{n-1}!\geq 2$$ $$a_{n-2}>a_{n-1}\geq3 \Rightarrow a_{n-2}!\geq 2^2$$ $$...$$ $$a_{2}\geq n-1 \Rightarrow a_{2}!\geq 2^{n-2}$$ Then, if we assume such an $m$ exists, then: $$(2^{n-4})^{m}>a_1^m=a_2!a_3!...a_n!+1\geq 2^{1+2+...+(n-2)}=2^{\frac{(n-2)(n-1)}{2}}$$ leading to $$(n-2)(n-1)<2m(n-4)$$ which only starts showing possible solutions for $m\geq5$.