Define $$S(m,n):=\sum _{k=0}^n \left(\sum _{j=0}^k \binom{n}{j}\right)^m$$
Then $S(1,n)$ is trivial and by elementary manipulations $S(2,n)=\left(\frac{n}{2}+1\right) 4^n-\frac{1}{2} n \binom{2 n}{n}$.
The first problem: How to prove $S(3,n)=\left(\frac{n}{2}+1\right) 8^n-\frac{3}{4} n 2^n \binom{2 n}{n}$ as mentioned by Foreman?
The second problem: Is there a general closed-form for $S(m,n)$? According to OEIS the answer is probably no, so a recurrence formula on $m$ is also welcomed. Thanks in advance!
We denote with $A_k=\sum_{j=0}^k\binom{n}{j}$ and have to show $S(3,n)=\sum_{k=0}^nA_k^3$. We need two intermediate results which are interesting by its own and which are shown at the end of this post:
The following is valid for $0\leq k\leq n-1$:
\begin{align*} A_k+A_{n-1-k}&=2^n\tag{2}\\ \sum_{k=0}^{n-1}A_kA_{n-1-k}&=\frac{n}{2}\binom{2n}{n}\tag{3} \end{align*}
Comment:
In (4) we use the symmetry $\sum_{k=0}^nA_k^3=\sum_{k=0}^{n}A_{n-k}^3$.
In (5) we apply $x^3-y^3=(x-y)\left(x^2-xy+y^2\right)$.
In (6) we use the identity from (2).
In (7) we use again the symmetry as we did in (4).
In (8) we use the identity from (3) and write $S(2,n)=\sum_{k=0}^nA_k^2$.
In (9) we use the result $S(2,n)=(n+2)2^{2n-1}-\frac{n}{2}\binom{2n}{n}$.
Comment:
In (10) we change the order of summation in the second sum $j\to n-1-k-j$ and use the identity $\binom{p}{q}=\binom{p}{p-q}$.
In (11) we shift the index in the second sum to start with $k+1$.
Comment:
In (12) we change the order of summation $l\to n-1-k-l$ and we use the identity $\binom{p}{q}=\binom{p}{p-q}$.
In (13) we exchange the two left-most sums respecting the index region $0\leq j\leq k\leq n-1$ and factor out $\binom{n}{j}$.
In (14) we exchange the two right-most sums respecting the index region $j\leq k<l\leq n$ and factor out $\binom{n}{l}$.
In (15) we simplify and write the index region somewhat more conveniently.
In (16) we substitute $q=l-j$.
In (17) we apply the identity $\binom{p}{q}=\binom{p}{p-q}$.
In (18) we apply Vandermonde's identity.
In (19) we write $q\binom{2n}{n+q}=(n+q-n)\binom{2n}{n+q}$ and apply the identity $\binom{p}{q}=\binom{p-1}{q}+\binom{p-1}{q-1}$.
In (20) we use the telescoping property of the sums.
In (21) we use the identity $\binom{p}{q}=\frac{p}{q}\binom{p-1}{q-1}$.