Reasons for slow Simplex Performance

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Could someone please list the main reasons why a linear are model is running slow and how to avoid them?

Speed improvement Tipps are also welcome.

I did some tests with a quite large linear model and ended up having different performances. One thing I realized was that if I have coefficients > 1 in the objective function it slows down the performance quite a lot.

I used lpsolve as simplex solver.