Given a non-constant integral irreducible monic polynomial $f(x)$, the prime factors of its value at integers $x\in\mathbb{N}$ forms a set $\mathcal{P}(f)$.
Is it possible that $\mathcal{P}(f)\cap\mathcal{P}(g)=\emptyset$ for two such polynomials $f$ and $g$.
Let $f(y)=y^2-2$, and let $g(x)=x^3+5$, then this works, because if they had a solution in common you'd have a solution for $y^2=x^3+7$, but this is known not to have any integer solutions. See Silverman's Arithmetic of Elliptic curves page 296.