I was trying to explain Galois theory to a non-specialist and was given a question I couldn't solve to my satisfaction, apologies if I have missed something obvious.
By Galois theory, a polynomial $f(x) \in K[x]$ is solvable by radicals (which I take to mean: there is a closed-form expression only involving addition, subtraction, multiplication, division, and taking $n$th roots) if and only if the Galois group of $F/K$ (where $F$ is the splitting field of $f(x)$, some subfield of $\mathbb{C}$) is solvable.
I'm a little vague on the details of how $f(x)$ being solvable by radicals corresponds to the existence of a general equation, but my understanding is that because a polynomial of degree 4 or less always corresponds to a Galois group that is solvable, any such polynomial is solvable. This is why we can find a general formula for the roots. On the other hand, the splitting field of a quintic can sometimes have Galois group $S_5$, which is not solvable, so in general quintic polynomials can't be solved by radicals. Therefore there cannot be a general formula.
The question then, is what happens if $K = \mathbb{C}$? Then any polynomial $f(x) \in K[x]$ already splits, because $\mathbb{C}$ is algebraically closed, and the Galois group is trivial and solvable. Or, if $K = \mathbb{R}$ then either $f(x)$ splits, or has complex roots in which case the relevant extension is $\mathbb{C}/\mathbb{R}$ with Galois group $C_2$, also solvable. In either case, it seems that Galois theory should imply that $f(x)$ is solvable by radicals. This must be wrong, because otherwise we could just embed $\mathbb{Q}[x]$ into $\mathbb{C}[x]$ and the quintic with rational coefficients would be solvable.
Putting aside rational polynomials, if $f(x) \in \mathbb{C}[x]$ with complex coefficients, is this now solvable by radicals?
A polynomial $f\in F[x]$ being solvable by radicals over $F$ means that there is some radical extension of $F$ where $f$ splits. Note, this is dependent on the field $F$. For example, for $a,b,c\in\mathbb{Q}$, the equation $ax^2+bx+c=0$ is solvable by radicals over $\mathbb{Q}$, because its roots are: (assume $a\ne 0$)
$x_{1,2}=\frac{-b\pm\sqrt{b^2-4ac}}{2a}$
Which are elements in a radical extension of $\mathbb{Q}$. Note that this element contains only scalars from the field (like $2,4$) and roots of some order.
Now, not every quintic polynomial in $\mathbb{Q}[x]$ is solvable by radicals over $\mathbb{Q}$. For example, $f(x)=x^5-6x+3$ is not solvable. You can take any expression as above, which contains rational scalars and roots of arbitrary order, and you will never get a root of this $f$. On the other hand, if you allow the expression to contain complex scalars then trivially you can get the roots of $f$, just take its roots (which are valid expressions if you allow complex scalars) and you are done. So yes, every polynomial is solvable by radicals over $\mathbb{C}$. But not necessary over $\mathbb{Q}$.
So this implies that there is no general formula over $\mathbb{Q}$, i.e a formula which contains the coefficients of the polynomial and rational scalars. Now of course we can ask the question - is there a general formula over $\mathbb{C}$, i.e such that contains complex scalars. (that is, it might contain scalars like $i$ or $2-\pi i$, unlike the quadratic formula which only contains rational scalars like $2$ and $4$) We know every specific polynomial is solvable over $\mathbb{C}$, but is there a general formula? The answer is still no. If you are familiar with transcendental extensions, you can read my answer here:
implication of the Abel–Ruffini theorem