It seems like I do understand what it means - to be "unique up to isomorphism". I'll try to formulate brief yet rigorous explanation (rather than just definition) in terms of equivalence relations.
So, let's take something really simple. How about toy-set $S = \{ \frac{1}{2}, \frac{2}{3}, \frac{3}{4} \}$ containing only those 3 elements and good-old well-know equivalence relation $(=)$?
(1) There are infinitely many bijections (also known as 'isomporhisms') from $f : S \mapsto S'$, for example: $S' = \{ \frac{2}{4}, \frac{4}{6}, \frac{6}{8} \}$, which, gathered all together, form yet another set $Iso(S)$.
(2) moreover: $\forall f \in Iso(S), \forall (s \in S, f(s)): s = f(s)$, i.e. defined equivalence relation holds.
In other words, none $S, S'$ are exactly identical, but all of them preserve somewhat particular equivalence relation. And that's why those are said to be unique up to a bijection (or an 'isomorphism'): no narrower uniqueness exists.
Did I miss something important?
It doesn't really make sense to talk about "unique up to isomorphism" without some context. The way it virtually always shows up is you have some particular property, $P$, and you want to say any $X$ such that $P(X)$ holds is unique up to isomorphism. This simply means that for any other $Y$ for which $P(Y)$ holds, $X\cong Y$. If we wanted to say that given any $X$ such that $P(X)$ holds was simply unique, we'd have a formula like $\forall X,Y.(P(X)\land P(Y))\implies X=Y$. For unique up to isomorphism, this just becomes $\forall X,Y.(P(X)\land P(Y))\implies X\cong Y$.
In many cases in category theory, we actually have that things are "unique up to unique isomorphism", which simply means that there is exactly one isomorphism $X\cong Y$ when $P(X)$ and $P(Y)$ both hold.
As a final caveat, usually what the property $P$ is being applied to is not a single object but rather a collection of objects and arrows, e.g. the categorical product is talking about an object and two arrows (the projections). However, it is common to talk just about the object part and leave the arrows implicit. Related to this, we are usually considering isomorphisms in categories other than $\mathbf{Set}$, e.g. for the categorical product we'd be considering a category of cones, say.