Unusual function format and its partial derivatives.

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I came across a function of this format:
$z = f(u,v)$ where $u = x^2y^2$ and $v = 5x + 1$

Because this function is not in the same format of the ones I've seen before (explicit or implicit), I don't know how to find (or even to do a single solving step!) its partial derivatives.

Basically, I need to show that:
$\frac{\partial^2z}{\partial x\partial y} = 4xy\frac{\partial f}{\partial u} +4x^3y^3\frac{\partial^2f}{\partial u^2} +10x^2y\frac{\partial^2f}{\partial v \partial u}$

Anyone could tell me how I should approach this type of problem?
Thanks!

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Yes this is a function. You can think of this as a composition of two functions

$z=f(u,v)=f(x^2y^2,5x+1)=g(x,y)$

and to answer your question, you need the chain rule for multivariable functions...applied twice. The chain rule in this case is

$\frac{\partial z}{\partial x}=\frac{\partial z}{\partial u}\frac{\partial u}{\partial x}+\frac{\partial z}{\partial v}\frac{\partial v}{\partial x}$

and then similarly

$\frac{\partial z}{\partial y}=\frac{\partial z}{\partial u}\frac{\partial u}{\partial y}+\frac{\partial z}{\partial v}\frac{\partial v}{\partial y}.$

So first take the partial w.r.t $y$

$\frac{\partial z}{\partial y}=\frac{\partial z}{\partial u}\frac{\partial u}{\partial y}+\frac{\partial z}{\partial v}\frac{\partial v}{\partial y}=\frac{\partial f}{\partial u}\cdot2x^2y+\frac{\partial f}{\partial v}\cdot0=2x^2y\cdot\frac{\partial f}{\partial u}$

and then apply $\frac{\partial}{\partial x}$ to this quantity using the product and the chain rule and then simplify.