Okay, so I had this idea for a presheaf that is quite peculiar. Instead of being based on algebraic category (i.e. abelian groups), it is based on a topological one, the category of compact topological spaces.
Okay, so let's say you have a space $X$. An open space $U$ is associated with the its one-point compactification, $U^*$. For each pair $V \subseteq U$, we have a continuous map $\text{res}_{V,U}: U^* \to V^*$ defined as
$$\text{res}_{V,U}(x) = \begin{cases} x & \text{if $x \in V$} \\ \infty & \text{if $x \in U \backslash V \vee x = \infty$} \end{cases}$$
$\text{res}_{U,U}=\text{id}_{U^*}$ and $\text{res}_{U,V} \circ \text{res}_{V,W} = \text{res}_{U,W}$ trivially. Therefore, this forms a presheaf.
My question is what is the sheafification of this presheaf? (I'm hoping it will be some sort of localized compactification!)
This is only a partial answer, but it's too long for a comment, so I'll post this as an answer and hope that nobody complains.
For simplicity, let's call your presheaf $\mathcal{F}$.
First, let's look at the stalk:
The stalk $\mathcal{F}_x$ is just going to be the direct limit (with respect to the restriction you defined) of the spaces $U^*$ with $U$ an open neighborhood of $x$. This is just going to be the space $$\mathcal{F}_x = \left(\bigcap_{U \ni x} U\right) \cup \{\infty\}$$ with the topology in which the only non-trivial open set is $\{\infty\}$.
A special case: the space is $T_1$
That $X$ is $T_1$ is equivalent to the intersection of the neighborhoods around $x$ being $\{x\}$ for every $x$. In this case, $\mathcal{F}_x = \{x\}^* = \{x,\infty\}$ with the topology $\{\emptyset,\{\infty\},\{x,\infty\}\}$. Recall that the sheafification $\mathcal{F}^{sh}(U)$ is a subset of $\prod_{x \in U} \mathcal{F}_x$, and in particular, since each $\mathcal{F}_x$ contains two distinguished points, this can be identified with the subsets of $U$, i.e. by looking at where this is not $\infty$. With this identification, $$\mathcal{F}^{sh}(U) = \{A \subseteq U \colon A~\mathrm{discrete}\}.$$ By a discrete space, I just mean every point is open. Restriction from $U$ to $V$ is just $A \mapsto A \cap V$.
Remark
Even for nice spaces, this sheafification will typically be pretty large. In particular, for our $T_1$ case, every finite subset is discrete!