What to do with symmetric but not essentially self-adjoint operators

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If we have a densely defined and symmetric operator on a Hilbert space, which is not even essentially self-adjoint, what can we do with it? It is at least closable, but i cannot really find/think of any other nice things we can say about it.

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A canonical case of a symmetric operator is $A=\frac{1}{i}\frac{d}{dx}$ on the domain $\mathcal{D}(A)$ consisting of all absolutely continuous functions $f\in L^2[0,\infty)$ for which $f'\in L^2[0,\infty)$ and $f(0)=0$. This operator $$ A : \mathcal{D}\left(A\right)\subset L^2[0,\infty]\rightarrow L^2[0,\infty) $$ is closed. And it is symmetric operator because $$ \langle Lf,g\rangle-\langle f,Lg\rangle=\frac{1}{i}\int_0^{\infty}f'\,\overline{g}+f\overline{g'}dx=\left.\frac{1}{i}f\overline{g}\right|_{0}^{\infty}=0,\;\; f,g\in\mathcal{D}(L). $$ The theory of this operator involves the Laplace transform and holomorphic functions on the upper half plane, which includes index theory, and other interesting aspects of holomorphic function theory. The associated holomorphic function theory can be studied on the unit disk instead, but it really came from here.

General symmetric operators can be decomposed into multiple copies of the operator $A$ and a self-adjoint operator, which may be $0$.