When is a second order differential equation not transformable into Sturm Liouville form?

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I've learned that a second order equation is transformable into SL using the integrating factor $F(x)=\exp\int^{x}{\frac{r(u)-p'(u)}{p(u)}du}$.

But are all second order diff eq's transformable or are there exceptions?

For example, if a second order doesn't have a weight ($\rho(x) = 0$) can it still be transformed into SL?