Let $F$ be a field, and $a_1, ... , a_n \geq 1$ integers. When is the polynomial $$f = X_1^{a_1} \cdots X_n^{a_n}-1$$ irreducible in $F[X_1, ... ,X_n]$?
I believe this should be the case if and only if $d = \gcd(a_1, ... , a_n) = 1$. At least for $F = \mathbb{C}$, the examples I've computed indicate this to be true.
If $d > 1$, then $f$ is not irreducible, since $$f = (X_1^{a_1/d} \cdots X_n^{a_n/d} - 1)[\sum\limits_{i=0}^{d-1} (X_1^{a_1/d} \cdots X_n^{a_n/d})^i]$$
I haven't been able to show the converse yet.
This is true, and can be seen easily using the Newton polytope of the polynomial and Minkowski sum of polytopes, look for this.
Try to prove that if $F=G*H$, then all the exponents $(b_1,...,b_n)$ of $G$ and $H$ must belong to the segment joining $(0,...,0)$ and $(a_1,...,a_n)$.
Hint: Prove that