"A strategy cannot be plausibly chosen by a rational player if and only if it is never a best response."
I understand the logic behind neglecting the strategies that are strictly dominated. But why can't there exist a strategy (which is never a best response) which supports a nash equilibrium mixed strategy ?
Because in a best response mixed strategy, every component pure strategy is again a best response strategy. And in fact, the converse is true too. This is a basic result proved by Nash himself in the early days. A version of the proof is given under proposition 3.1 of this paper on algorithmic game theory.