The way I understand things, roughly speaking, the importance of smooth manifolds is that they form the category of topological spaces on which we can do calculus. The definition of smooth manifolds requires that they be paracompact. I've looked all over, but I haven't found a clean statement for how paracompactness is a necessary condition to do calculus.
I understand that, by a theorem of Stone, every metric space is paracompact, but I'm not sure why we need global metrizability either.
Question: In what sense is paracompactness exactly the right condition to impose on a topological manifold to allow us to do calculus on it? Is there some theorem of the form "X has [some structure we strictly need in calculus] if and only if it is paracompact"?
A) For a differential manifold $X$ the following are equivalent:
Partitions of unity are a fundamental tool in all of differential geometry (cf. kahen's answer) and would suffice to justify these conditions but the other equivalent properties can also be quite useful .
B) However occasionally non paracompact manifolds have been studied too. For example:
Edit As an answer to Daniel's question in the comments below, here are a few random examples of consequences of the existence of partitions of unity on a differential manifold $M$ of dimension $n$.
A sophisticated point of view (very optional !)
All sheaves of $C^\infty_M$-modules (for example locally free ones, which correspond to vector bundles) are acyclic in the presence of partitions of unity.
This has as a consequence that paracompact manifolds behave like affine algebraic varieties or Stein manifolds in that you can apply to them the analogue of Cartan-Serre's theorems A and B.
This is, in my opinion, the deep reason for the usefulness of partitions of unity on a manifold. (The last bullet for example was directly inspired from its analogue on affine varieties or Stein manifolds)