Green's theorem is
$$\oint_{\partial D} (P\, dx+Q\, dy) = \iint_D dx\,dy \: \left ( \frac{\partial Q}{\partial x} - \frac{\partial P}{\partial y}\right)$$
where one can see that the RHS is asymmetric in $x$ and $y$. Why is this, and what is the physical significance?
I suspect the answer has to do with using a right-handed coordinate system (e.g. one can use Stokes' theorem to show the above, which involves a vector product, which is right-handed), or possibly that the boundary is traversed anti-clockwise, but I'm unable to make any deeper or more accurate statement than that...
Both the left side and the right side are asymmetric in $x$ and $y$: The boundary $\partial D$ goes around $D$ in a particular direction and not in the other direction.