Why is $x^6-x^5 + x^3 - x^2 + 1$ irreducible over $\mathbb{Z}[x]$?
It clearly has no integer roots, and in fact no real roots. Every polynomial with real coefficients can be written as a product of quadratic and linear terms. But I'm not sure how to factor the above polynomial. Maybe some sort of theorem involving irreducible integer polynomials might be useful?
Let $f(x) = x^{6} - x^{5} + x^{3} - x^{2} + 1 \in \mathbb{Z}[x]$. Consider the polynomial $g(x) = f(x+2) = 37 + 120x + 165x^2 + 121x^3 + 50x^4 + 11x^5 +x^6$. We note that the coefficients are all positive and bounded by $165$. We have that $g(172) = 27592587407701$ and $g(172)$ is prime. By Cohn's Criterion , $g(x)$ is irreducible in $\mathbb{Z}[x]$, and it follows $f(x)$ is irreducible in $\mathbb{Z}[x]$. A bit overkill, but it gets the job done.