I found out this problem on Geogebra but I can't prove it. Please help me. Thanks
Let $ABC$ be an acute triangle with circumference $(O)$. The tangents at $B, C$ of $(O)$ intersects at $D$. The tangent of $(O)$ at $A$ intersects the line $BC$ at $M$. $AD$ intersects $(O)$ at $E$. Now prove that $ME$ is the tangent of $(O)$ at $E$.

Hints towards a solution. If you're stuck, explain what you've tried.
The setup is quite complicated. How can we simplify it?
One approach to prove perpendicularity is to show that
This approach allows us to "remove" $A$ via the substitutions $MA^2 = MB \times MC$ and $AO^2 = R^2$.
Now, we want to show that $MB \times MC - OB^2 = MD^2 - DO^2$. This becomes a condition only about $B, C$ and their common tangent $D$, and any point $M$ on line $BC$.
I assure you this is true, and again there are multiple ways of doing this (Pythagorean theorem, Coordinate geometry, brute force, etc), so pick an approach and push it through.
Note: There are other ways of proving perpendicularity too. EG It's very easy (and arguably easier than recognizing the above) to coordinate geom / brute force the entire setup.