H.G Wells' short story The Plattner Story is about a man who somehow ends up being "inverted" from left to right. So his heart has moved from left to right, his brain, and any other asymmetries belonging to him. Then H.G Wells' goes on a slight metaphysical exposition:
There is no way of taking a man and moving him about in space, as ordinary people understand space, that will result in our changing his sides. Whatever you do, his right is still his right, his left his left. You can do that with a perfectly thin and flat thing, of course. If you were to cut a figure out of paper, any figure with a right and left side, you could change its sides by simply lifting and turning it over. But with a solid it is different. Mathematical theorists tell us that the only way in which the right and left sides of a solid body can be changed is by taking that body clean out of space as we know it, - taking it out of ordinary existence, that is, and turning it somewhere outside space. This is a little abstruse, no doubt, but anyone with a slight knowledge of mathematical theory will assure the reader of its truth. To put the thing in technical language, the curious inversion of Plattner's right and left sides is proof that he has moved out of our space into what is called the Fourth Dimension, and that he has returned again to our world.
This is leaving me a bit perplexed. A reflection is an odd isometry after all, and rotations/translations are direct. So it shouldn't be possible for the man to be reflected using continuous,direct transformations, regardless of how many dimensions he is using. But then again, his argument with the 2/3D analogue is convincing... Thoughts and explanations?
I think the key here is that a flat object living purely in the $xy$-plane is not affected by reflection in $z$. Thus, an apparent reflection across the $x$-axis can be achieved by reflecting across both the $x$ and $z$ axes — this is a net rotation and hence can be achieved by continuous transformation without breaking orientability.
The same principle would apply to a 3D object embedded in $\mathbb R^4$. Having no width along the fourth dimension makes one invariant under reflections across that dimension.