I've thought about the following result, which I wanted to verify:
Let $X$ be a topological space where $\vert X\vert>1$ generated by a collection of subsets $\{ S_\alpha \}_{\alpha\in \Lambda}$, such that $\cup_{\alpha\in \Lambda} S_\alpha \neq X$, then $X$ is not a $T_1$ space.
My reasoning for this is that if $X$ is a topological space with more than one point, and it has a point $x\in X$ without a proper neighbourhood, then $\overline{ \{x \} }=X$. This follows from the fact that $y\in X$ is in $\overline{E}$ if and only if $U\cap E\neq \emptyset$ for any neighbourhood $U$ of $y$.
Is this logic sound? I am currently trying to deduce conditions from a generating collection about whether it does not satisfy separation axioms, so if there is a similar stronger result I would be happy to be informed of it.
Let's see, consider $X=\{1,2\}$ with topology $\tau=\big\{\emptyset,\{1\},\{1,2\}\big\}$. Note that $(X,\tau)$ satisfies your assumption, since it is generated by $\big\{\{1\}\big\}$. Clearly the only open neighbourhood of $2$ is $X$ itself. But $\{2\}=X\backslash\{1\}$ is closed, i.e. $\overline{\{2\}}=\{2\}$.
It's the other way around: under your assumption the only point that has a chance of being closed is the special one you've chosen.
Assume that $x_0\in X$ is a point such that $X$ is the only open neighbourhood of $x_0$ (such point exists by your condition). It follows that $x_0$ belongs to the closure of any subset of $X$. In particular $x_0\in\overline{\{x\}}$ for any $x\in X$. Thus almost all (possibly except $x_0$) points are not closed. Hence $X$ is not $T_1$.