Can we "integrate" functors?

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Let $F:\mathcal{C}\rightarrow \mathcal{C}'$ be a functor between "nice" (e.g. abelian with enough injectives) categories. If F is not exact we can form the derived functors $F',F'',...$ Is it possible to reverse this process ("integrate" $F$) or stated reversely: Are there nice conditions on a functor $F$ to be a derived functor?