For a separable Hilbert space $H$, and $$ D:{\frak dom}(D) \subseteq H \to H $$ a closed operator, it is possible that $D$ has trivial resolvent. In the other words, is it possible that $T - \lambda$id$_H$ does not admit a bounded inverse, for all $\lambda \in \mathbb{C}$.
Moreover, we know that if $T$ is self-adjoint, then it has non-empty resolvent since, for example, $i$ cannot be in the spectrum. However, if $T$ is merely closed and symmetric, or just symmetric, will the resolvent still be empty?
Unbounded operators can have empty resolvent set. Consider the unbounded operator on $L^2\left(\mathbb{R}^2\right)$ given by multiplication by $x_1+ix_2$, with domain given by all $u\in L^2(\mathbb{R^2})$ such that $(x_1+ix_2)u\in L^2\left(\mathbb{R}^2\right).$ I'll leave it to you to verify that is an operator with empty resolvent.