Composition of Differential Operators

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If I have:

$A=\partial_x^2+u(x)$

$B=u(x)\partial_x$

How do I compose: $AB$ and $BA$?

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This is just usual composition of functions: for all $f$ in an appropriate domain $(AB)(f)=A(B(f))=(\partial^2_x+u)(u\partial_x f)=\partial^2_x (u\partial_x f)+u^2\partial_x f=\cdots$ using the chain rule, and similarily for $BA$. Notice that $u$ acts as a multiplication operator. Apart from that, it is totally crucial for composition that you specify both domain and codomain of $A$ and $B$ and in particular what is assumed about $u$ (say domain and codomain is $C^\infty$, and $u$ be also of class $C^\infty$).