Counting negative eigenvalues of a non self-adjoint operator

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I know for the self-adjoint operators there is a robust theory for counting the eigenvalues based in Sturm-Liouville theory, even for differential operators of order greater than 2 (Greenberg has a lot of works in this line).

I'm trying to count the negative eigenvalues of the operator $=\partial_x^4 −\partial_x^2+\partial_x^2(())$ with $()$ smooth and rapidly decaying as $\to±\infty$. This operator is non-self-adjoint, the continuum spectrum is [0,∞), and the eigenvalues are real. But I'm not sure if the classical Sturm-Liouville Theory can be applied in this case.

In seeking out references for the theory of Sturm-Liouville theory in non-self-adjoint operator with order greater than 2, I have come across papers over particular results but nothing that clear my doubt. Thus my question:

Is there a book or paper that goes over the basics of non-self adjoint operators?

Is the hypothesis of self-adjoint essential in the Sturm-Liouville Theory?