A classic example of a fractal curve is the Koch Snowflake. This is a topological manifold (as opposed to many other fractals which are not), but it also clearly not smooth.
Question: Are there any curve-type fractals that are actually smooth? Or does the infinite self-similarity eventually pose an insurmountable barrier to smoothness?
Technically speaking, $\mathbb{R}$ is a smooth fractal too, so for the above question, I'd only introduce the caveat that the curve be 'interesting' as a fractal (or at least non-trivial).
Intuitively, I see no reason for such objects to not exist, but this is far from any area of math I'm familiar with.
I think, it depends on the precise notion of self-similarity and smoothness in your question. In my answer I consider planar curves which are self-similar with respect to affine transformations. De Rham curves provide examples of self-similar curves in this sense. Parabola is self-similar and smooth. More interestingly, there are other de Rham curves which are merely $C^1$-smooth, see the discussion in:
V.Protasov, On the regularity of de Rham curves, Izvestia Math., 2007
freely available here.
My guess is that the only $C^2$-smooth affine self-similar planar curves are algebraic of degree $\le 2$.
Update. It took me awhile to find proper references, but here it goes. First of all, by a self-similar subset of $E^n$ I will mean the limit set $\Lambda$ of an "iterated functional system" of a collection of contracting maps $S_1,...,S_k$ of $E^n$, which belong to some group $G$ of transformations of the Euclidean space or the extended Euclidean space. The most commonly considered groups are:
The group $Sim(E^n)$ os Euclidean similitudes (compositions of Euclidean rigid motions and dilations).
The group $Aff(E^n)$ of affine transformations.
The group $Mob(S^n)$ of Moebius transformations.
I will restrict to the case $n=2$, just for simplicity, much of what I will say holds in higher dimensions as well.
V. Mayer, M. Urbański, Finer geometric rigidity of limit sets of conformal IFS. Proc. Amer. Math. Soc. 131 (2003), no. 12, 3695–3702.
C. Bandt, A. Kravchenko, Differentiability of fractal curves. Nonlinearity 24 (2011), no. 10, 2717–2728.