My attempt:
Let $A_{1}$ denotes where 123 occurs, $A_{2}$ denotes where 321 occurs, $A_{3}$ denotes where 456 occurs, and $A_{4}$ denotes where 654 occurs. Also $|U|$=6!
$$\begin{aligned}|A_{1} &\cup A_{2} \cup A_{3} \cup A_{4}|\\ &= |A_{1}|+|A_{2}|+|A_{3}|+|A_{4}|\\ &\quad -(|A_{1}A_{2}|+|A_{1}A_{3}|+|A_{1}A_{4}|+|A_{2}A_{3}|+|A_{2}A_{4}|+|A_{3}A_{4}|)\\ &\quad +|A_{1}A_{2}A_{3}|+|A_{1}A_{2}A_{4}|+|A_{1}A_{3}A_{4}|+|A_{2}A_{3}A_{4}|\\ &\quad-|A_{1}A_{2}A_{3}A_{4}|\\ =& \ ? \end{aligned}$$
Then,
$$\begin{aligned}|A_{1}'A_{2}'A_{3}'A_{4}'|& =|U|-|A_{1} \cup A_{2} \cup A_{3} \cup A_{4}|\\ &= 6!-? \end{aligned}$$
I am pretty sure this is ALL wrong. Please help me with this problem. Thank you!
Your approach is quite ok.