The given expression simplifies to $$\sin^{-1}(\sin 2)-\cos^{-1}(\cos 2)+\tan^{-1}(\tan 4)-\cot^{-1}(\cot 4)+\sec^{-1}(\sec 6)-\csc^{-1} (\csc 6)$$
$$=(\pi-2)-2+(4-\pi)-(2\pi-4)+(2\pi-6)-(2\pi-6)$$ $$=-2\pi+4$$
But the given answer is $5\pi-16$. I rechecked all the the principle branches, and they all seem to be right. Where did use the wrong value?
These type of questions are very easy to handle by graphs. Just remember their graphs and for finding the value at each point, see the location of that point and write the equation of the line by seeing it's slope and the point where it cuts the $x$ axis and you will get the value. For example, you have to find $\csc^{-1}(\csc 6)$, in it's graph note that $6$ lies in between $\frac{3\pi}{2}$ and $2\pi$ and the line has a positive slope and the cutting point with $x$ axis is $x=2\pi$ and hence the equation of the line would be $y=x-2\pi$.
So your mistakes were $\cot^{-1}(\cot 4)=\pi-4$, not $2\pi-4$, and secondly $\csc^{-1}(\csc 6)=6-2\pi$ and not $2\pi-6$. Hence the correct answer will come out to be $5\pi-16$.