In elementary probability class, we are taught simple examples such as,
Tossing a coin, generating the sample space $S = \{H,T\}$.
Rolling a die, generating the sample space $S = \{1, 2, 3, 4, 5, 6\}$
Simple examples like this. Here, it is easy to define random variable $X$ that maps each point $w \in S$ into a real number $X(w) \in \mathbb{R}$.
However, in real life, we might deal with the following examples.
Generate a picture using a neural network, the sample space is the space of all pictures $S = \{\text{every picture}\}$
or
mapping the thoughts of a human into an EEG electrical signal, $S = \{\text{thoughts}\}$.
In these cases, is it still possible to use probability at all?
The sets are "abstract" or in more concrete terms uncountably infinite.
If we cannot even describe what this set is, how can we proceed to describe a random variable $X$? How can we even say that one exists?
We have no idea how this random variable even works or how it should be defined? Then how do we describe distributions of random variables?
In fact, a majority of modern research in probability theory is concerned with uncountable sample spaces. Look no further than the two most fundamental objects in all of probability: the uniform $[0,1]$ random variable, and the Brownian motion $B_t$. The former has sample space $\Omega=[0,1]$ and the latter has sample space $C_0([0,1])$, the space of all continuous functions on $[0,1]$ started from $0$.
Mathematicians are accustomed to working with objects like $\mathbb R$ and function spaces, and at this point have a very precise understanding of these objects. In many regards (especially concerning calculations) it is no more difficult than working with a finite sample space - and sometimes easier, since the infinite objects often follow simpler patterns.
And of course, it all uses the apparatus of measure theory, as already mentioned in the comments.
Being able to literally map an abstract concept into physical life has little bearing on the mathematical reasoning required... and in a sense that is the point of mathematics.
Furthermore, I disagree with your assessment that we cannot describe a set which is uncountably infinite. It is no different than saying that you cannot describe a glass of water, since you cannot manage to count each molecule of water in your lifetime...