Let $P=(p_1,p_2)$ be a point on an semicircle and $r$ be the line perpendicular to the radius $\overline{OP}$, like the picture below.
Euclid showed (Book III, Proposition 16) that $r$ does not intersect the semicircle at any point other than $P$.
I'd like help to show that $r$ satisfies the calculus definition of the tangent line to the semicircle at $P$. For this, we have to show that if $y$ is the function whose graph is the semicircle, then $$\lim_{x\to p_1}\frac{y(x)-y(p_1)}{x-p_1}$$ exists.
Since the slope of $\overline{OP}$ is $-p_2/p_1$ we know that the value of the limit have to be $\displaystyle \frac{p_1}{p_2}=\frac{p_1}{y(p_1)}$.
This is a part of the John Molokach's proof of the Pythagorean Theorem. So, we can not use the expression $y(x)^2=|\overline{OP}|^2-x^2$.
Thanks.
EDIT. Possible answer to my question: (Is it right?) It is enough to prove that the limits $$\lim_{x\to p_1^+}\frac{y(x)-y(p_1)}{x-p_1}\tag{1}$$ and $$\lim_{x\to p_1^-}\frac{y(x)-y(p_1)}{x-p_1}\tag{2}$$ exists and are equal. Given $x\in(p_1,0)$, consider the lines $s(x)$, $t(x)$ and $u(x)$ as in the picture below.
Notice that $$\text{slope of }t(x)\leq\text{slope of }s(x)\leq\text{slope of }r=\frac{p_1}{y(p_1)}.$$ So, if we assume $y$ continuous, we conclude that $$\lim_{x\to p_1^+}[\text{slope of }t(x)]=\lim_{x\to p_1^+}\frac{x}{y(x)}=\frac{p_1}{y(p_1)}.$$ It follows from the squeeze theorem that $$\lim_{x\to p_1^+}[\text{slope of }s(x)]=\frac{p_1}{y(p_1)}.$$ This shows that the limit $(1)$ exists and is equal to $p_1/y(p_1)$ because $$\frac{y(x)-y(p_1)}{x-p_1}=\text{slope of }u(x)=\text{slope of }s(x).$$
The limit $(2)$ can be dealt analogously and a similar reasoning works if $p_1>0$.


I don’t know how much of the development of Calculus you want to use. If you’re willing to accept an answer that doesn’t proceed directly from the definition, but uses techniques at some remove from the definition, then try this:
You might as well assume that your circle is the unit circle, $x^2+y^2=1$. Using implicit differentiation, $2x\,dx+2y\,dy=0$, thus $\frac{dy}{dx}=-x/y$. The tangent to the circle at point $(a,b)$ thus has slope $-a/b$, while the slope of the radius is $b/a$. Each of these slopes is the negative reciprocal of the other, so the tangent is perpendicular to the radius.