In the single dimensional case, it is the case that $E((X-E(X))(Y-E(Y)))$ corresponds to the covariance between X and Y. However, in the multidimensional setting, the covariance matrix of the multivariate random variable W is defined by $E((X-E(X))(X-E(X)^T))$.
I am therefore curious about whether or not there is an interpretation of $E((X-E(X))(E(Y-E(Y))^T)$, as this seems to be a multidimensional analogue of the covariance formula, however, this does not correspond to the covariance matrix of a random variable.
Is the resultant matrix used in any contexts, and if so what is its interpretation?
This is called the joint covariance matrix for the random vectors. It is the matrix of covariances of members of each random vector.
$${[\mathsf{Cov}(X,Y)]}_{i, j}=\mathsf{Cov}(X_i,Y_j)$$
(it is sometimes also referred to as the cross-covariance matrix).